Reframing translational research as transactional research:

Reframing research on faculty development.

Research on faculty development has focused primarily on individual participants and has produced relatively little generalizable knowledge that can guide faculty development programs. In this article, the authors examine how current research on faculty development in medical education can be enriched by research in related fields such as teacher education, quality improvement, continuing medic...

Scenarios Research and Cognitive Reframing: Implications for Strategy as Practice

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

Translational Research

Treatment of dominantly inherited muscle disorders remains a difficult task considering the need to eliminate the pathogenic gene product in a body-wide fashion. We show here that it is possible to reverse dominant muscle disease in a mouse model of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a common form of muscular dystrophy associated with a complex cascade of epigenetic events f...

Reframing research on intuitive science knowledge

Education research has devoted significant effort to understanding the intuitive knowledge students bring to bear in reasoning about formal science. In addition to documenting the specific content of students’ conceptions in particular domains, some researchers attempt to make more general claims, both within and across domains, about the nature of intuitive knowledge. These attempts involve an...